The AAMLS 2023 Scientific Committee invites submission for oral / poster presentations on all aspects of Medical Laboratory Sciences that have not previously been published or presented.
To submit an abstract, please register for the Congress and login using your registered email address to upload your abstract under Abstract Submission section (My Page)
Or you can also download the Abstract Submission Form and email the completed form together with your abstract to This email address is being protected from spambots. You need JavaScript enabled to view it..
Important Dates
| Abstract Submission Deadline | 31 July 2023 31 August 2023 |
|---|---|
| Presenter’s Registration Deadline | 31 August 2023 |
| Presentation File Submission Deadline | 8 September 2023 |
The presenting author must register for the congress. Accepted abstracts whose presenting author does not register and pay in full by the above deadline, will not be published in the final abstract book.
Abstract Preparation Guidelines
The AAMLS 2023 Scientific Committee invites submission for oral / poster presentations on all aspects of Medical Laboratory Sciences that have not previously been published or presented.
Use the following excerpt as a format guide:
INVESTIGATION OF THE CHROMOSOME 6 INSTABILITY AND THE MAPK SIGNALING PATHWAYS IN HUMAN OSTEOSARCOMA
1 M. Rozi Ramli, 2 M.M. Hamdi, 3 Mohd Aminudin Mustapha 4 Mohamad Zulkarnaen Ahmad Narihan
1 Department of Pathology, Sarawak General Hospital (SGH), Jalan Hospital (SGH), Jalan Hospital, 93586 Kuching, Sarawak.
2 Department of Para-Clinical Science, Faculty of Medicine and Health Sciences (FMHS), UNIMAS, 94300 Kota Samarahan, Sarawak.
3 Pre-University Centre, UNIMAS,94300 Kota Samarahan, Sarawak.
4 Department of Pathology, FMHS, UNIMAS, 94300 Kota Samarahan, Sarawak.
*Presenter’s email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract
Osteosarcoma is the most common primary malignancy of bone with worldwide incidence of 2 to 3 million/year. This tumour usually develops at distal part of fast growing bone and associated with instability of chromosome 6. Despite that, the preceding molecular mechanism leading to the instability is not fully known. Following the local ethical committee review, from a total of 30 cases within 7years period (from October 2008 to October 2015). The study aimed to investigate the copy number of gene encoding vascular endothelial growth factor (VEGF) located at chromosome 6p21 using Fluorescence In Situ Hybridization (FISH) and the general chromosomal instability as indicated by micronuclei formation. In addition, VEGF, Hypoxia inducible factor (HIF) and p53 diagnostic immunohistochemistry (IHC) staining were performed as to investigate relationship of hypoxic stress and tumour growth suppress. Furthermore, the mitogen activated protein kinase (MAPK) cellular proliferation pathway molecules; ERK, p38 and JNK IHC were also examined. Our findings showed VEGF expression at both protein and gene level (6p21) indicating likelihood of neovascularization. On top of that, expressed ERK, p38 but not JNK; and expressed HIF & p53 in those cases suggest tumour cell survival by evading the natural cell death program, apoptosis. In conclusion, this study presented a possible molecular mechanism underlying chromosomal instability in human osteosarcoma.
Keywords: Osteosarcoma; mitogen activated protein kinase; chromosomal instability; 6p21
Abstract Review And Selection
Authors are encouraged to submit full paper and if selected by the Editorial Board, will be published as proceedings in the Malaysian Journal of Medical Laboratory Sciences (MJMLS).
The AAMLS 2023 Scientific Committee reserves the right to select papers relevant to the session. Presenters may present papers without having their papers published in congress proceedings or MJMLS.
